My current research has been looking at improving cardiac performance in many ways…
In patients with specific conduction abnormalities such as right bundle branch block, we are studying new pacing techniques to improve ejection fraction and cardiac output.
In patients with heart failure we are also looking at neuromodulation by pacing through the wall of the pulmonary artery and stimulating specific nerve groups that result in better left ventricular contractility.
We are studying long-term lead performance in women with submammary device placements.
We are currently involved in drug and device trials that study better pacing vectors in cardiac resynchronization therapy (CRT), autothreshold mechanisms in CRT, MRI safe devices, new downsized pacing leads, vagal nerve stimulation in heart failure, new oral medications to convert atrial fibrillation to sinus rhythm without electrical cardioversion, new catheter systems to better treat persistent atrial fibrillation, and subcutaneous defibrillator placement.
We are also studying techniques to decrease procedural times and costs such as AV nodal ablation from the pacemaker pocket and transseptal catheterization without using a needle device. We have many other “homegrown” projects looking at pre- and post-procedural care and testing to optimize patient satisfaction and outcomes.
Trends in the rates of hospitalizations for acute stroke among patients over 90 years of age with atrial fibrillation in the United States: from 2005 to 2014.
Shantha GP, Mentias A, Alqasrawi M, Qazi A, Inampudi C, Chaikriangkrai K, Deshmuk A, Bailin S, Giudici M, Mazur A.
J Geriatr Cardiol. 2017 Sep;14(9):547-552. doi: 10.11909/j.issn.1671-5411.2017.09.002.
Abnormal epicardial electrophysiologic substrate in patients with early repolarization pattern and reduced left ventricular systolic function: A report of two cases.
Krothapalli SM, Giudici M, Demetroulis E, Sigurdsson G, Goldsmith G, Mazur A.
HeartRhythm Case Rep. 2017 Jul 1;3(9):422-426. doi: 10.1016/j.hrcr.2017.06.009. eCollection 2017 Sep.
Sex-Specific Associations of Oral Anticoagulant Use and Cardiovascular Outcomes in Patients With Atrial Fibrillation.
Palamaner Subash Shantha G, Mentias A, Inampudi C, Kumar AA, Chaikriangkrai K, Bhise V, Deshmukh A, Patel N, Pancholy S, Horwitz PA, Mickelsen S, Bhave PD, Giudici M, Oral H, Vaughan Sarrazin MS.
J Am Heart Assoc. 2017 Aug 18;6(8). pii: e006381. doi: 10.1161/JAHA.117.006381.
Gender Differences in the Trends of Hospitalizations for Acute Stroke Among Patients With Atrial Fibrillation in the United States: 2005 to 2014.
Shantha GPS, Mentias A, Bhise V, Kumar A, Rasmussen T, Adams C, Chaikriangkrai K, Mohsen A, Alqasrawi M, Sigurdsson G, Deshmukh A, Bhave PD, Giudici M.
Am J Cardiol. 2017 Nov 1;120(9):1541-1548. doi: 10.1016/j.amjcard.2017.07.044. Epub 2017 Jul 31.
Nonlocality Induces Chains of Nested Dissipative Solitons.
Javaloyes J, Marconi M, Giudici M.
Phys Rev Lett. 2017 Jul 21;119(3):033904. doi: 10.1103/PhysRevLett.119.033904. Epub 2017 Jul 18.
Safety and effectiveness of a 6-French MRI conditional pacemaker lead: The INGEVITYTM clinical investigation study results.
Nielsen JC, Giudici M, Tolasana Viu JM, Chew E, Sommerijns E, Wold N, Evert L, Love CJ, Stein K, Olaf H.
Pacing Clin Electrophysiol. 2017 Oct;40(10):1121-1128. doi: 10.1111/pace.13159. Epub 2017 Sep 23.